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The Structural Genomics Consortium is a registered charity (Number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no
The primary pathological hallmark of PD is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta
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In human monocytes and macrophages, the inhibition of the autophagy pathway drives the formation of the NLRP3 inflammasome, while increased autophagic flux reduces the secretion of IL-1, suggesting the role of autophagy impairment in driving inflammasome activation [192]
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