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21 Its ability to aggregate in mitochondria has already been discovered since the 1960s, the mechanism of which has been thoroughly explored

Shawn Stevenson: Remember- what was it

Scans were obtained on a 3 T Magnetom Skyra or Vida MRI scanner (Siemens Healthineers, Erlangen, Germany) as previously published (Moss et al., 2018)

Collectively, these findings emphasize the multifactorial and hormone-sensitive nature of perimenopausal mood disorders, shaped by complex interactions among E2, progesterone, neurosteroids, neurotransmitters and neuroendocrine stress systems

More research combining host metabolites and microbiota is needed to fully understand these relationships