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In the presence of suitable precursors for GSH synthesis, cultured astrocytes can fully compensate for the exportmediated GSH loss by GSH de novo synthesis, even if Mrp1mediated GSH export was further stimulated (Arend et al

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The results showed that curcumin treatment caused reduction in pro-caspase-3, but triggered the presence of PARP-1 cleavage product in p53+/+ and p53/ HCT-116 cells
