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Metabolic pathway research, adipocyte behavior studies, mitochondrial efficiency analysis, and NAD+-related biochemical investigations

One analysis did report a reduced risk of melanoma, but this was a cancer-specific finding rather than evidence that high-dose B vitamins prevent cancer generally

2024 Jun 19;14(6):343

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In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]

It is also involved in energy production, via roles in fatty acid and amino acid metabolism