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3.3.1 Parkinsons disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded -synuclein, in dopaminergic neurons and likely contribute to the death of these neurons

mTOR: mechanistic target of rapamycin

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Diacylfuroxans are masked nitrile oxides that inhibit GPX4 covalently

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Many of the enzymes involved in lysine and threonine synthesis have been localized to plastids (Galili, 1995)