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VEGF is the main factor in stimulating tumor angiogenesis, which can promote the growth of vascular endothelial cells and induce vascular proliferation, which is closely related to tumor progression

Only female volunteers were enrolled to reduce gender variability and also because females are by far the majority of individuals who seek skin-whitening agents

The cAMP overshoot in an opioid dependent in vitro system may be precipitated by the addition of an antagonist such as naloxone, or by removing the agonist through washing the cells

This property is also due to the redox ability that VIC has, being able to transition between its reduced form and its oxidized form [6,41,42]

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