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GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management

Claims otherwise should be viewed with skepticism

These are favorable odds for a relatively low-risk intervention, but they underscore that peptide therapy does not work for everyone

AOD9604 vs Intact hGH in Obesity Models A direct head-to-head comparison of AOD9604 and intact hGH in obese and lean mice confirmed that both compounds significantly reduced body weight gain in obese animals through increased fat oxidation and lipolysis stimulation but that AOD9604 achieved this without the hGH receptor binding, IGF-1 stimulation, hyperglycaemia, or reduced insulin secretion associated with full-length hGH treatment

SS-31 has shown neuroprotective effects in preclinical models by preserving mitochondrial function, reducing oxidative stress, and promoting neuronal survival

In this study, we characterized the changes in neural functionality, secreted cytokine profiles, and gene expression in co-cultures of human iPSC-derived neurons and primary astrocytes in response to prolonged exposure to TNF- and IL-6