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The most common types of anemia are aplastic anemia, iron deficiency anemia, sickle cell anemia, thalassemia, and vitamin deficiency anemia

316,317,318 Lactate-induced extracellular acidosis blocks one-carbon metabolism that short-lived effector T cells are highly dependent on, subsequently bringing about decreased histone 3 lysine 27 trimethylation (H3K27me3) deposition of memory-related genes, thereby affecting differentiation, reserving sternness and facilitating anti-tumor cytotoxicity of T cells

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But rapid lipolysis creates a metabolic challenge most patients don't anticipate