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The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus

The combination gave good recovery of more hydrophilic analytes, but increased matrix effects for some compounds

Specifically, the malate/aspartate shuttle proteins MDH2, -KG/malate carrier, and GOT2 were found to be hyperacetylated leading to suppression of the transport and oxidation of cytosolic NADH in mitochondria, which correlated with decreases in oxygen consumption and cardiac energetics (manifested by a reduction in phosphocreatine/ATP) (42, 47)

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doi: 10.1016/j.autrev.2013.12.004 57 IacominoGRotondi AufieroVIannacconeNMelinaRGiardulloNDe ChiaraGet al

Das, UND Life Sciences, USA The article belongs to the special issue Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA