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Research has shown that High-dose intravenous methylprednisolone, commonly used in MS management, can lead to decreased levels of vitamin B12 and folate in the cerebrospinal fluid and serum of MS patients [147]

Une carence de cette vitamine provoque une altration de la maturation des prcurseurs mylodes et affaiblit ou dtriore la myline cause de laugmentation des niveaux dacide mthylmalonique

Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12

doi:10.1152/japplphysiol.00945.2010 Vukojevi J, Vrdoljak B, Malekinui D, et al

With methyl B12 treatment, this caveat cannot be overemphasized: In order to observe this therapys optimal effect, gastro-intestinal health needs to be optimized

This flexibility in administration routes offers practical advantages for addressing injuries in different body locations