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When ferroptosis is induced by exogenous or internal stimuli, polyunsaturated fatty acids (PUFAs) are oxidized by intracellular ROS that arise from iron-dependent Fenton reactions

Researchers found that TP can deplete GSH in liver cells and increase ROS, which induces oxidative stress (Li et al., 2014)

This latter role is, in fact, required for the synthesis of several proteins, in which its ability to donate methyl groups is essential for the synthesis of methylated compounds, while the inorganic sulfate is fundamental for the synthesis of sulfur-containing amino acids

3-Phosphoglycerate is the precursor of serine as well as phosphoglycerides (PG)

In some cases, such as certain oncology programs where the compound's risk profile makes it unsuitable for healthy subjects, patients may participate instead

This factor plays a major role in antioxidant response