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The expression and activities of GPX3 are changed in many pathological processes involved in systemic non-neoplastic disorders, such as kidney diseases, cardiovascular diseases, respiratory diseases, metabolic diseases, digestive system diseases, neurological disorders, bone and joint diseases, and other diseases (Figure 3)

doi: 10.1016/j.jmb.2006.10.011

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The molecular mechanisms underlying pain relief extend beyond simple ROS neutralization