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Methods A three-arm 16-week, double-blind, randomised, placebo-controlled trial, adjunctive to usual treatment, was conducted
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Chronic activation of inflammasome signaling in microglia and astrocytes, characterized by the upregulation of NLRP3 and NF-B, has been linked to the establishment of a neuroinflammatory environment, leading to synaptic loss and exacerbating tau pathology
