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(2010) demonstrated that an increase in neovascularization and intraplaque hemorrhage is correlated with adverse clinical cardiovascular outcomes

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Cellular senescence: It is a form of self-defense mechanism where there is a pause in cell division, but there isnt permanent death

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This process is glucose-dependent, occurring primarily when glucose levels are elevated, which minimizes the risk of hypoglycemia compared to agents like sulfonylureas (Dungan & DeSantis, 2026)

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