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In addition, AS-IV has been found to restore the expression of p62, a sortilin protein, by reducing the levels of cystatin-C (Cyt-C) and poly (ADP-ribose) polymerase (PARP), thus correcting the autophagy imbalance in cardiomyocytes caused by DOX (Luo et al., 2021b)

Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients

The mechanism behind this is still unclear, although mutations in ubiquitin-specific protease 8 ( USP8 ), a deubiquitinase enzyme with various targets including EGFR, leading to hyperactivation of this enzyme and subsequent increased EGFR deubiquitination and recirculation to the cell surface, enhance the release of ACTH (147,150)

"Cyanocobalamin."