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Description
The nuclear factor erythroid 2-related factor 2 (NRF2) is a fundamental regulator of cell antioxidant defense system, which modulates the expression of multiple antioxidant response element-dependent genes including NADPH-quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HMOX1), ferritin heavy chain 1 (FTH1), FPN1, GSH, and GPX4 (Hybertson et al., 2011
However, when analyzing the results of three randomized clinical trials (RCTs), the impact of magnesium supplementation on IR in these women was variable

Consequently, there is a need for long-term studies with more substantial participant numbers to verify the sustained effectiveness of NADH and CoQ10 in treating ME/CFS [129]
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Certain congenital conditions, such as hereditary intrinsic factor defects and congenital vitamin B12 malabsorption (Imerslund-Grsbeck disease), can also cause severe vitamin B12 deficiency

doi: 10.3168/jds.2013-7679 96 OwenJ
