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Consistent with these observations, single-cell and spatial transcriptomic analyses of AD brains repeatedly reveal downregulation of mitochondrial and bioenergetic gene programs within excitatory neuron populations (Zou et al., 2024)

3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors (Tangpong et al., 2011)

RahmanMSHossainKSDasSKunduSAdegokeEORahmanMAet al

Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells

Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), statins, histamine H2 receptor blockers, or vascular calcium channel blockers appears to prevent AD (Vagnucci and Li 2003)

Adv Pharmacol 38: 3-20
