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Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells

This includes the cGMP-PDE inhibitors, soluble guanylate cyclase (sGC) activators, PGI2 analogs, Ca 2+ -channel blockers, and ET-1 receptor antagonists

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Therefore, a greater ARG availability displaces ADMA from eNOS binding, thereby improving NO synthesis [7,27,40,54,59]

doi: 10.1016/j.ctim.2019.102234 96 TangJ.ShanS.LiF.YunP