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This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

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(2021) showed that synbiotics can significantly reduce pro-inflammatory cytokines and chemokines, alleviate intestinal inflammation and gut dysbiosis caused by high-altitude hypoxia, and improve gut barrier function