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Silibinin ameliorates fructose-induced lipid accumulation and activates autophagy in HepG2 cells

Aside from pan-acetylation of H3, we analyzed acetylation of H3K9 and H3K27, which are strongly associated with transcriptional activation and undergo dynamic changes during metabolic reprogramming ( 2 on acetylation of H3K9 and only minor effect on H3K27

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The mammalian genome actually encodes five distinct enzymes with thiolase activity as outlined in the following Table

To evaluate the collagen density, the tissue section was stained with Masson trichrome staining, while for the observation of fibroblasts, the skin tissue section was stained with HematoxylinEosin Staining