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N -homocysteinylation involves the modification of protein lysine residues and can alter or impair the protein structure and function, resulting in protein damage

Additional studies have probed gene expression differences between three matched patient-derived GBM cultures of GSCs and differentiated GBM cells (DGCs) [65]

The long-term intravenous (IV) application of OHCbl is impracticable for the patients

Downstream signalling may then include manipulation of IGF-1 pathways, PI3K/Akt and MAPK/ERk cascades or endocrine feedback systems

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The evidence base is not human clinical data, but it is far more extensive than KPV's body of work