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In mothers, elevated hCG levels may disrupt dopamine and serotonin signaling, contributing to mood disorders, memory deficits, and anxiety, while also being linked to gestational hypertension and pre-eclampsia, which can impair cerebral perfusion and promote neuroinflammation [135]

Kaczorowska A, Malinga-Drozd M, Kaas W, Kopaczyska M, Woowiec S, Borowska K

One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle

Science, 364 (6441):685689, May 2019

Biomedicines 12(1):127

Hao et al (2016a) show that PIK3CA mutation causes elevated expression of GPT2, an aminotransferase that transfers amino group from glutamate to pyruvate to generate alanine