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thus it seems highly likely that these processes occur in konzo, a motor neuron disease triggered in part by the consumption of toxic compounds that are well established to increase oxidative stress 43

Lipoic acid was found to effectively slow disease progression when administered either orally (87), intraperitoneally (88), or subcutaneously (89) to mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis

Similar to ISCs, low intracellular ROS levels are required for the maintenance of quiescence in mouse and human airway basal stem cells (ABSCs) (130)

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