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Effect of the KD on the cortex metabolome Based on the quantified metabolites in the cortex, we observed a statistically significant difference by group (PERMANOVA

Their group also revealed that 9-ING-41 significantly enhanced 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) antitumor activity in chemo-resistant PDX models of GBM by decreasing tumor size and increasing overall survival (119)

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doi: 10.1016/j.cbpb.2008.08.009

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Notably, only six of the 12 participants improved, five stayed the same, and one did worse, calling the data into question