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(2025) 188:557688.e17

Int Immunopharmacol 20(1):148156

Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor

Despite the current advent of multiple immunotherapies, they have not significantly improved the overall survival of patients with glioma, which is associated with a suppressive immune microenvironment in glioma cells

In addition, when reaching the acidic tumor microenvironment, the nanoprobe co-encapsulating sonosensitizer and immune agonist swells, which results in an accelerated drug release under ultrasound irradiation to induce a combined immune response, ultimately leading to a robust anticancer effect