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This suggested that SF was exerting a pharmacodynamic action that reflected induction of GSTs by SF, thereby shunting the reactive epoxide intermediate away from nucleophiles in DNA, where it would have mutagenic and carcinogenic effects, and toward GSH, which allowed it to be further metabolized and excreted in the urine

104 People with diabetes frequently have lower amounts of zinc compared to the nondiabetic population

Adjacent sections were stained either with H&E or with periodic acid-Schiff (PAS) techniques, as previously described (38, 40)

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Insulin resistance: STAT3/SOCS signaling suppresses insulin/IGF-1 pathway The signaling pathways of several cytokines and growth factors, such as insulin/IGF-1, converges at the activation of STAT3 factor (Figs