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at the same time, persistent antigen stimulation in the TME can induce the gradual loss of PGC1 in CD8+ T cells via the Akt signaling pathway, affecting mitochondrial replication, gradually reducing the cells ability to utilize lipids, and triggering CD8+ T cell exhaustion (111)

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Indeed, some consider that the triacylglycerol content of HDL may be a better practical marker for metabolic and cardiovascular risk