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However, it is crucial to keep in mind that if, at the end of corticosteroid and antiviral treatment, symptoms reappear with a decrease in ACTH levels, this could indicate potentially permanent pituitary damage (pituitary atrophy) (245, 246)

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Given that the lifespan extension by early-life rapamycin treatment in Drosophila is reported to be dependent on intestinal autophagy 13 and that MetR in autophagy-defective yeasts has been shown to fail to extend their lifespan 67 , upregulation of autophagy in the gut or other tissues could be a key mechanism for MetR-induced longevity programme

As you sit down to design your next study, ask yourself these questions: What is my primary hypothesis

Mutations in UVSSA cause UV sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair