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Thus, while NAD + supplementation may be the canonical role of niacin, there are other important pathways that mediate its effects in the body, particularly in the CNS

Narita, Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence

Disclosure of interest: Name of author: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.10 - ESUS/CRYPTOGENIC STROKE P330 - ESOC25-180 LEFT VENTRICULAR DISEASE AS A RISK FACTOR FOR ADVERSE OUTCOMES AND STROKE RECURRENCE IN PATIENTS WITH EMBOLIC STROKE OF UNDETERMINED SOURCE Angelo Cascio Rizzo 1 , Ghil Schwarz, Andrea Bonelli 1 , Andrea Magi 2 , Elio Agostoni 1 , Antonella Moreo 1 , Maria Sessa 1 ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy, 2 University of Milano-Bicocca, Milan, Italy Background and Aims: LV disease (LVD), such as mild-to-moderate LV dysfunction and LV wall-motion-abnormalities (LVWMA), are considered potential minor cardiac sources in ESUS, but their role is underexplored

Frequency sweep measurements were performed at 5% strain and a frequency range of 500 to 0.1 rad s 1