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Decades of research have increased our understanding of Fc domain interactions with dif-ferent Fc receptors and assisted in engineering antibodies with desir-able effector functions

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Following incubation with primary antibody, the sections were incubated for 2 h in biotinylated goat antirabbit secondary antibody diluted 1:500 in 0.01 M PBS and subsequently incubated with ABC reagents (Standard Vectastain ABC Elite Kit