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By inhibiting NNMT, 5-Amino-1MQ reduces the production of 1-methylnicotinamide (MNA), a metabolite that would otherwise deplete cellular nicotinamide pools

Adequate studies in humans have not been conducted

Researchers are investigating whether NNMT inhibition modulates the cellular metabolic responses to repeated contractile stress, potentially explaining the differential metabolic profiles observed when combining NNMT inhibition with exercise protocols in research models

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The main risks stem from its unapproved status and potential for improper compounding

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