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23 The type 1 IGF receptor gene is expressed by almost all tissues and cell types during embryogenesis

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These include neurodegenerative diseases such as Parkinson's Disease and Alzheimer's Disease, autoimmune disorders like Multiple Sclerosis, and conditions affecting cognitive and physical function such as Autism and Chronic Fatigue Syndrome

Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and 1-integrin signaling pathway in tumor cells
