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In 2009, the US Food and Drug Administration designated pyridoxamine as a pharmaceutical, when it became the active ingredient in Pyridorin, a drug designed by Biostratum Inc., and investigated for possible utility in diabetic nephropathy due to its ability to decrease the production of advanced glycation end products (AGE) in animal models of diabetes

Song K, Kong X, Zhang Z, Xian Y, He M, Zhang Y, et al

Thus, relying on BCVA to assess a treatment aimed at modifying drusen biology may not accurately reflect efficacy

Luettig J, Rosenthal R, Barmeyer C, et al
Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of ampk/mtor signaling
