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In agreement, mice deficient for Bach1, a negative regulator of the HO-1-inducing transcription factor Nrf2 (151), have dramatically higher HO-1 expression in the heart and display resistance to ischemia-reperfusion-induced myocardial injury (61, 152)

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After adding MTT dye and incubating it for 4 hours, formazan crystals were formed

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