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The unbound solution was kept as a mitochondrial-free cytosolic fraction
Given that studies utilising BNIP3 and BAX/BAK1 have demonstrated that their inhibition or genetic deletion impacts apoptotic and necrotic markers 2,17 , it is reasonable to hypothesise that BNIP3, as a BH3-only protein activator, functions upstream of BAX and/or BAK1
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[DOI] [PubMed] [Google Scholar] 46.Vairetti M., Griffini P., Pietrocola G., Richelmi P., Freitas I
& Hassan, A
Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment
