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Excessive ECM combined with inadequate remodeling of scar tissue results in an aesthetically and functionally unsatisfactory, painful, pruritic scar that can impair function

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The delayed onset of RTT symptoms is believed to be associated with the postnatal accumulation of methylated CpA dinucleotides (mCpA) and MECP2 binding to these sites, contributing to progressive neurodevelopmental abnormalities (110)

To unbiasedly investigate the effect of high GSH on tissue homeostasis, we next performed RNAseq analysis on the tissues with the greatest increase in GSH with GshF expression, the kidney and lung (Fig

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