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However, the translation of these findings from the laboratory to the clinic requires careful and rigorous investigation to ensure safety and efficacy in human patients

This was done in a double-blind, placebo-controlled fashion

doi: 10.3389/fbioe.2022.983872

Mayo Clinic notes that there is no solid proof B12 injections help with weight loss in people who are not deficient
It is not produced by the body and must be obtained externally through diet, supplementation, or direct administration

J Clin Invest 90 : 23482354 Biolo G et al
