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2022) Furthermore, TMAO reduces bile acid production by suppressing CYP7A1 and CYP27A116 and restricts bile acid enterohepatic circulation by repressing the organic anion transporter and the expression of the multidrug resistance protein family
GLP-1 agonists like semaglutide have undergone extensive clinical trials involving tens of thousands of participants

The research was performed in facilities renovated with support from the National Institutes of Health (RR015468-01)
(33176370) It may be necessary to adjust the dose of other drugs that the patient is on (e.g., phenytoin and valproate)

doi: 10.1111/and.13953 [DOI] [PubMed] [Google Scholar] 82

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