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Although traditional clinical trials, such as the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 study, demonstrated neutral effects on the progression of DKD in non-selective cohorts, certain subgroup analyses indicated a potential reduction in albuminuria among early-stage DKD patients (110)

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Our findings of higher maternal vitamin B-12 concentration after supplementation and the finding of increased breast milk and infant plasma vitamin B-12 concentrations suggest that supplementation with vitamin B-12 during pregnancy can have an effect on infant vitamin B-12 status and health outcomes

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