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The mean age was 67 (SD12), 38.4% were female, and the median NIHSS was 3 (IQR14)

Alcohol and its metabolite acetaldehyde exert a direct toxic effect to the intestinal tight junctions with a redistribution of ZO-1 and occludin (152, 153)
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In recent years, interest has arisen in the potential use of thymulin as a therapeutic agent

Intravenous administration of direct NAD + has been carried out in humans 66,116,117 , but the human trials were conducted in extremely small cohorts
