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Selective estrogen receptor modulators (SERMs) like raloxifene have demonstrated variable effects, with some reducing lesion size in preclinical models but limited clinical applications due to scarce and low-quality evidence

In both cases, trialists responded positively to new results reporting requirements, with NIH-funded trials reporting their results in greater than 50 percent of cases between 2008 and 2019, and industry funders reporting results in greater than 50 percent of cases between 2008 and 2018