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extra B12 is excreted if levels are normal Weight Loss: little evidence B12 shots cause weight loss Mood: helps if mood issues come from deficiency but not a standalone depression treatment The key takeaway is that B12's benefits come from correcting a deficiency, not supplying extra boosts to healthy individuals

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Furthermore, a similar results were reported in a study of individuals with or without oligozoospermic which showed no significant association between DNA methylation in spermatozoa and the MTHFR C677T genotypes although a trend for higher incidence of methylation alterations in severe oligozoospermic infertile men with CT genotypes were observed 34 , suggesting that a much more complicated or indirect interactions between MTHFR polymorphism and methylation are involved