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Interestingly, it can take years for B12 stores to deplete to a point where a deficiency becomes apparent: Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment

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Pregnant women may notice an alteration in the appearance and color of their urine, ranging from pale yellow to deep amber

Physical examination revealed erythema, papules, and thickened plaques in the hands and both upper limbs, with (SCORAD: 48.4

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