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The results showed: miR-21, miR-34a, miR-92a, miR-126, and miR-200c are jointly increased in ME/CFS patients compared to healthy controls.[ref] MiR-21 and miR-126 regulate eNOS and endothelial function.[ref] MiR-21 is found abundantly in macrophages and plays a key role in regulating the anti-inflammatory response in macrophages.[ref] Immune response, cellular energy: A study involving 40 ME/CFS patients and 20 healthy controls found five upregulated miRNAs (miR-127-3p, miR-142-5p, miR-143-3p, miR-150-5p, and miR-448), and one downregulated (miR-140-5p)

[21] did not show any modification in the content of carnitine in the muscle after a single intravenous dose of 185 mol/kg

doi: 10.7326/0003-4819-132-4-200002150-00004 62 GluvicZSudarETicaJJovanovicAZafirovicSTomasevicRet al

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233 MichaudLTouijerKAMauguenAZelefskyMJMorrisMJLyashschenkoSKet al

*The beneficial effect is obtained with a daily intake of 10 g of linoleic acid (LA)