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In a normal oxygenated tissue, the exposed Salmonella are vulnerable to being neutralized by the host immune system ( Salmonella in the TME ( 2.2 Passive accumulation and vascular effects In addition to active chemotaxis, the pathophysiological characteristics of the tumor vasculature also support bacterial enrichment through passive transport-related mechanisms and vascular effects

Marees, T

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Feng Z, Hensley L, McKnight KL, Hu F, Madden V, Ping L et al

Additionally, in cisplatin-treated EGFR-mutant lung adenocarcinoma lines, early DTPs downregulate proliferation genes and upregulate lipid-kinase network components such as SOCS1, which has been correlated with poor clinical outcome in treated patients (Chavez-Dominguez et al., 2023)

This treatment may be preceded by a 3-to-6-month course of antithyroid drug therapy to deplete their glands of stored thyroid hormone, a program that lessens any chance of an exacerbation of the heart disease caused by a radioiodine-induced release of thyroid hormone from the gland