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What Happens When VIP Is Low or Dysfunctional Low VIP signaling has been associated with: Chronic inflammatory states Increased intestinal permeability Impaired immune tolerance Autonomic nervous system imbalance Neurocognitive symptoms Increased susceptibility to environmental stressors Importantly, low VIP is rarely a primary problem

Once an mtDNA mutation reaches an appreciable level within cells, the percentage of mutant mtDNAs can drift by replicative segregation

Semiautomatic segmentation of VOIs on CT scans was based on Hounsfield Unit (HU) thresholds, as described in previous publications 48,62

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PLoS ONE 11 , e0155660 (2016)