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Conversely, VTA DA neurons, which are less vulnerable than SNpc DA neurons, generate broad spikes and are autonomous pacemakers, but have smaller Cav1 channel currents and a strong intrinsic calcium buffering by calbindin

10.1016/j.redox.2022.102573 81 LauritsenK

Researchers also revealed that mCRC patients with elevated HER2 expression demonstrated poor responses to anti-EGFR therapy such as cetuximab (Bertotti et al., 2011), which is related to lung metastases and poor OS (Sartore-Bianchi et al., 2019)

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Cysteine residues of proteins with a low pKa are targets for redox modulation under oxidative or nitrosative stress conditions

In the early stages, fine hand movements may slow down, arm swings may decrease, gait may change, or there may be subtle tremors