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PMNs isolated from mice lacking both DAP12 and FcR have defects in ROS production, indicating the critical and redundant roles of these proteins in promoting oxidative burst (Mocsai et al., 2006

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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Sullivan M.R., Danai L.V., Lewis C.A., Chan S.H., Gui D.Y., Kunchok T., Dennstedt E.A., Vander Heiden M.G., Muir A

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5.3 ROS production 5.3.1 Neutrophil-derived ROS in atherosclerosis Within neutrophils, three protein components (MPO, NADPH oxidase, and lactoferrin) participate in redox reactions, capable of generating ROS