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It gets damaged, stops functioning, or dies

Limitations The lack of any measurement of nitric oxide production, which could have provided us with valuable mechanistic insights into nitric oxide metabolism, is a limitation of the present study

Some chronic conditions require multiple treatment cycles to achieve maximum improvement

Study JMDB excluded patients with an Eastern Cooperative Oncology Group Performance Status (ECOG PS of 2 or greater), uncontrolled third-space fluid retention, inadequate bone marrow reserve and organ function, or a calculated creatinine clearance less than 45 mL/min

4-HNE is a major end product of lipid peroxidation that is present in normal human plasma at concentrations ranging from 0.1M to 1.4M and this can increase more than 10 folds during oxidative stress in vivo [84]