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Conclusions Nrf2 is a master regulator of several protective stress response pathways and it is not surprising that it became a highly competitive target for pharmacological modulation (Cuadrado et al
The correct intervention is peptide discontinuation or dose reduction, or switching to an anticoagulant without antiplatelet overlap (heparin instead of warfarin, for example)
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Thus, further studies are mandatory to better understand the mechanisms by which the combination of folic acid and -tocopherol acts to prevent neurodegeneration for the rational design of new therapeutic approaches
Chem Sci 2018, 9 (38), 75107519
